The first truly organised persecution of Christians came after the Great Fire of Rome in 64 AD under the Emperor Nero. Looking for a scapegoat in the devastating aftermath of the fire, he found it in the Christians. He would blame them for the fire because of their apocalyptic belief that Rome and the world would end by fire. This led to an active and organised campaign against them. The second and third centuries sporadically saw more of the same prosecutions, especially under the reign of Emperors Decius and Valerian. The last and truly terrible persecution of Christians occurred at the beginning of the fourth century. A general edict of persecution, under the authority of Emperor Diocletian, was published on February 24th, 303 AD. Interestingly, on the day before the edict was published, Diocletian ordered…
Source: The Great Persecution – If It Happened Yesterday, It’s History